1. BIOMARKER IDENTIFICATION AND DEVELOPMENT OF NEW DIAGNOSTIC SYSTEMS FOR ACUTE KIDNEY INJURY

Project 1.1. Pre-emptive diagnosis of acquired AKI risk: identification and modelling of risk factors and biomarkers

Project 1.2. Differential etiopathological diagnosis of AKI: complex AKI modelling and multiparametric, new biomarker-based diagnostic algorithm development

Project 1.3. Development of companion diagnostics to pre-emptively monitor drug nephrotoxicity

2. DEVELOPMENT OF A DIAGNOSTIC SYSTEM TO PRE-EMPTIVELY MONITOR SYSTEMIC AND RENAL HEMODYNAMICS AND PRE-RENAL AKI

Project 2.1. Pathophysiology of systemic and renal hemodynamics in relation to pre-renal AKI

Project 2.2. Systems medicine modelling of systemic and renal hemodynamics and biomarker identification

Project 2.3. Mathematical modelling and prototype diagnostic software development

3. PATHOPHYSIOLOGY AND BIOMARKERS OF ACUTE KIDNEY INJURY SEQUELAE AND TRANSITION TO CHRONIC KIDNEY DISEASE

Project 3.1. Characterization of subclinical AKI sequelae and identification of subclinical biomarkers

Project 3.2. Pathophysiology of AKI-to-CKD transition and identification of subclinical biomarkers

4. DEVELOPMENT OF AN INTEGRAL, MULTIPLEX AKI DIAGNOSTIC SYSTEM PROTOTYPE

5. IDENTIFICATION AND DEVELOPMENT OF PROPHYLACTIC DRUGS AND FOOD SUPPLEMENTS TO PREVENT ACUTE KIDNEY INJURY

Project 5.1. Natural flavonoids

Project 5.2. Nanoencapsulated quercetin

Project 5.3. Endogenous trophic factors

6. PATHOPHYSIOLOGY OF RENAL FIBROSIS IN CHRONIC KIDNEY DISEASE

Project 6.1. Role of Ras family members in renal fibrosis

Project 6.2. Role of ALK1 in renal fibrosis

Project 6.3. Role of BMP9 in renal fibrosis

Project 6.4. Role of cardiotrophin-1 in CKD pathophysiology

7. IDENTIFICATION AND DEVELOPMENT OF BIOMARKERS AND DIAGNOSTIC SYSTEMS TO DETECT AND MONITOR HYPERTENSIVE AND DIABETIC TARGET ORGAN DAMAGE

Project 7.1. Clinical evaluation of endoglin as indicator of target organ damage

Project 7.2. Clinical evaluation of osteoprotegerin as indicator of target organ damage

Project 7.3. Clinical evaluation of cardiotrophin-1 indicator of target organ damage