Grupo de Investigación Traslacional en
Enfermedades Renales y Cardiovasculares
Tenemos un interés especial en conocer, poder detectar y mejorar el manejo de la enfermedad subclínica y, muy especialmente, el riesgo individual de padecerla, para anticiparnos y prevenirla.
Para ello usamos un abordaje multidisciplinar que combina de forma sinérgica la experimentación biomédica preclínica, la investigación clínica y la inteligencia artificial, en un entorno cooperativo internacional.
Nuestro objetivo último es generar conocimiento fisiopatológico y productos y aplicaciones útiles para los pacientes, y para ello tenemos una colaboración estrecha con la industria farmacéutica y biotecnológica.
Proyectos destacados
y líneas de investigación
Proyecto AKIprev
Desarrollo de un sistema de diagnóstico basado en biomarcadores renales en pacientes oncológicos tratados con inmunoterapia.
Líneas de investigación
FISIOPATOLOGÍA
INTEGRADA
Abordaje, disección y modelado integral de procesos fisiológicos
y patológicos renales y cardiovasculares.
DIAGNÓSTICO PREVENTIVO
Y DE PRECISIÓN
Una nueva estrategia para la detección del riesgo de desarrollar la enfermedad renal.
TRATAMIENTO
PREVENTIVO
Desarrollo de terapias basadas en actuar sobre los mecanismos de la
enfermedad.
TOXICOLOGÍA
RENAL
• Tratamientos antioxidantes para la prevención de la nefrotoxicidad farmacológica.
• Nuevos sistemas de diagnóstico y monitorización de la toxicidad renal.
Publicaciones
López-Hernández FJ.Cell Surface Area to Volume Relationship During Apoptosis and Apoptotic Body Formation.
Cellular Physiology and Biochemistry
DOI: 10.33594/000000369
Fuentes-Calvo I, Martinez-Salgado C.Sos1 Modulates Extracellular Matrix Synthesis, Proliferation, and Migration in Fibroblasts.
Frontiers in Physiology
DOI: 10.3389/fphys.2021.645044
Casanova AG, Prieto M, Colino CI, Gutiérrez-Millán C, Ruszkowska-Ciastek B, de Paz E, Martín Á, Morales AI, López-Hernández FJ.A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity.
International Journal of Molecular Sciences
DOI: 10.3390/ijms22020729.
Paniagua-Sancho M, Quiros Y, Casanova AG, Blanco-Gozalo V, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, Sancho-Martínez SM, López-Hernández FJ.Urinary plasminogen activator inhibitor-1: A biomarker of acute tubular injury.
American Journal of Nephrology
DOI: 10.1159/000518455
Docherty NG, Delles C, D’Haese P, Layton AT, Martínez-Salgado C, Vervaet BA, López-Hernández FJ.Haemodynamic frailty-A risk factor for acute kidney injury in the elderly.
Ageing Research Reviews
DOI: 10.1016/j.arr.2021.101408
Ortega-Loubon C, Martínez-Paz P, Garcia-Moran E, Tamayo-Velasco A, López-Hernández FJ, Jorge-Monjas P, Tamayo E.Genetic susceptibility to acute kidney injury.
Journal of Clinical Medicine
DOI: 10.3390/jcm10143039
Muñoz-Félix JM, Martínez-Salgado C.Dissecting the Involvement of Ras GTPases in Kidney Fibrosis.
Genes (Basel)
DOI: 10.3390/genes12060800
Sancho-Martínez SM, Blanco-Gozalo V, Quiros Y, Prieto-García L, Montero-Gómez MJ, Docherty NG, Martínez-Salgado C, Morales AI, López-Novoa JM, López-Hernández FJ.Impaired tubular reabsorption is the main mechanism explaining increases in urinary NGAL excretion following acute kidney injury in rats
Toxicological Sciences
DOI: 10.1093/toxsci/kfaa029
Casanova AG, Vicente-Vicente L, Hernández-Sánchez MT, Prieto M, Rihuete MI, Ramis LM, Del Barco E, Cruz JJ, Ortiz A, Cruz-González I, Martínez-Salgado C, Pescador M, López-Hernández FJ, Morales AI.Urinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterations
Biomedicine & Pharmacotherapy
DOI: 10.1016/j.biopha.2019.109684
Casanova AG, Hernández-Sánchez MT, Martínez-Salgado C, Morales AI, Vicente-Vicente L, López-Hernández FJ. A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: Implications for clinical application
Critical Reviews in Toxicology
DOI: 10.1080/10408444.2020.1837070
Prieto-Garcia L, Vicente-Vicente L, Blanco-Gozalo V, Hidalgo-Thomas O, Garcia-Macias MC, Kurtz A, Layton AT, Sanz A, Morales AI, Martinez-Salgado C, Pericacho M, Sancho-Martinez S, Lopez-Hernandez FJ. Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury.
Laboratory Investigation
DOI: 10.1038/s41374-020-0473-9
Martin WP, White J, López-Hernández FJ, Docherty NG, le Roux CW.Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease
Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.00289
Sancho-Martínez SM, Sánchez-Juanes F, Blanco-Gozalo V, Fontecha-Barriuso M, Prieto-García L, Fuentes-Calvo I, González-Buitrago JM, Morales AI, Martínez-Salgado C, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Novoa JM, López-Hernández FJ.Urinary TCP1-eta: A cortical damage marker for the pathophysiological diagnosis and prognosis of acute kidney injury.
Toxicological Sciences
DOI: 10.1093/toxsci/kfz242
Sánchez-Garrido AI, Prieto-Vicente V, Blanco-Gozalo V, Arévalo M, Quiros Y, López-Montañés D, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JM.Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice.
Journal of Clinical Medicine
DOI: 10.3390/jcm8122086
Casanova AG, Hernández-Sánchez MT, López-Hernández FJ, Martínez-Salgado C, Prieto M, Vicente-Vicente L, Morales AI.Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity
European Journal of Clinical Pharmacology
DOI: 10.1007/s00228-019-02771-5
Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Pescador M, López-Hernández FJ, Morales AI.A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity.
Toxicology
DOI: 10.1016/j.tox.2016.12.003
Prieto García L, Pericacho M, Sancho-Martínez S, Sánchez A, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.Mechanisms of Triple Whammy Acute Kidney Injury.
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2016.07.011
Quirós Y, Blanco-Gozalo V, Sanchez-Gallego JI, López-Hernández FJ, Ruiz J, Perez de Obanos MP, López-Novoa JM.Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats.
Pharmacological Research
DOI: 10.1016/j.phrs.2016.02.025
Gamella-Pozuelo L, IFuentes-Calvo I, Gómez-Marcos MA, Recio-Rodriguez JI, Agudo-Conde C, Fernández-Martín JL, Cannata-Andía JB, López-Novoa JM, García-Ortiz L, Martínez-Salgado C.Plasma cardiotrophin-1 as a marker of hypertension and diabetes-induced target organ damage and cardiovascular risk.
Medicine
DOI: 10.1097/MD.0000000000001218
Vicente-Vicente L, Sánchez-Juanes F, García-Sánchez O, Blanco-Gozalo V, Pescador M, Sevilla MA, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
Toxicology Letters
DOI: 10.1016/j.toxlet.2014.11.033
García-Sánchez O, Sancho-Martínez SM, López-Novoa JM, López-Hernández FJ.Activation of the ALK-5 pathway is not per se sufficient for the antiproliferative effect of TGF-β on renal tubule epithelial cells.
Cellular Physiology and Biochemistry
DOI: 10.1159/000430246
Sancho-Martínez SM, Prieto-García L, Blanco-Gozalo V, Fontecha M, López-Novoa JM, López-Hernández FJ.Urinary proteomics in renal pathophysiology: Impact of proteinuria.
Proteomics Clinical Applications
DOI: 10.1002/prca.201400183
Blázquez-Medela M, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.Increased KLK9 urinary excretion is associated to hypertension-induced cardiovascular damage and renal alterations
Medicine
DOI: 10.1097/MD.0000000000001617
Muñoz-Félix M, González-Núñez M, Martínez-Salgado C, López-Novoa JM.TGF-β and BMPs inhibitors in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2015.10.003
Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C.Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.
Kidney International
DOI: 10.1038/ki.2013.292
Gomez-Marcos MA, Gonzalez-Sarmiento R, Recio-Rodríguez JI, Agudo-Conde C, Gamella-Pozuelo L, Perretta-Tejedor N, Martínez-Salgado C, García-Ortiz L.Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case–control study protocol (LOD-Hipertensión).
BMJ Open
DOI: 10.1136/bmjopen-2014-005112
Blázquez-Medela AM, García-Sánchez O, Blanco-Gozalo V, Quiros Y, Montero MJ, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
PLoS One
DOI: 10.1371/journal.pone.0105988
Rodríguez-Peña A, Fuentes-Calvo I, Docherty N, Arévalo M, Grande MT, Eleno N, Pérez-Barriocanal F, López-Novoa JM.Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy.
BioMed Research International
DOI: 10.1155/2014/124902
García-Sánchez O, López-Novoa JM, López-Hernández FJ.Interferon-γ Reduces the Proliferation of Primed Human Renal Tubular Cells.
Nephron Extra
DOI: 10.1159/000353587
Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM, Ruiz-Ortega M, Egido J, Burkly LC, Martinez-Salgado C, Ortiz A.TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.
Biochimica et Biophysica Acta-Molecular Basis of Disease
DOI: 10.1016/j.bbadis.2013.05.032
Fuentes-Calvo I, Crespo P, Santos E, López-Novoa JM, Martinez-Salgado C.The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.
Biochimica et Biophysica Acta – Molecular Cell Research
DOI: 10.1016/j.bbamcr.2013.07.008
Rossi E, Sanz-Rodriguez F, Eleno N, Düwel A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C.Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
Blood
DOI: 10.1182/blood-2012-06-435347
Ghosh S, Kapil V, Fuentes-Calvo I, Bubb K, Pearl V, Milsom A, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb W, Caulfield M, Hobbs A.Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Hypertension
DOI: 10.1161/HYPERTENSIONAHA.111.00933
Ferreira L, Fuentes-Calvo I, Muñoz-Félix JM, Muñiz C, Sánchez-Juanes F, Raposo C, González-Buitrago JM, López-Novoa JM, Martínez-Salgado C.Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.
Electrophoresis
DOI: 10.1002/elps.201100606
Sancho-Martínez SM, Prieto-García L, Prieto M, López-Novoa JM, López-Hernández FJ.Subcellular targets of cisplatin cytotoxicity: an integrated view.
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2012.07.003
López-Hernández FJ, López-Novoa JM.Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects.
Cell Tissue Research
DOI: 10.1007/s00441-011-1275-6
Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C.H-Ras isoform modulates extracellular matrix synthesis, proliferation and migration in fibroblasts.
American Journal of Physiology (Cell Physiology)
DOI: 10.1152/ajpcell.00103.2011
Sancho-Martínez SM, Piedrafita FJ, Cannata-Andía JB, López-Novoa JM, López-Hernández FJ.Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis.
Toxicological Sciences
DOI: 10.1093/toxsci/kfr098
Sánchez-González PD, López-Hernandez FJ, Morales AI, Macías-Nuñez JF, López-Novoa JM.Effects of deferasirox on renal function and renal epithelial cell death.
Toxicological Letters
DOI: 10.1016/j.toxlet.2011.03.018
López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López Hernández FJ.Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.
Journal of Translational Medicine
DOI: 10.1186/1479-5876-9-13
Ferreira L, Quiros Y, Sancho-Martínez SM, García-Sánchez O, Raposo C, López-Novoa JM, González-Buitrago JM, López-Hernández FJ.Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.
Kidney International
DOI: 10.1038/ki.2010.439
Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ.New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view.
Kidney International
DOI: 10.1038/ki.2010.337
Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arévalo M, Leverve X, López-Novoa JM, El-Mir MY.Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.
Kidney International
DOI: 10.1038/ki.2010.11
Garcia-Ortiz L, Ramos-Delgado E, Recio-Rodriguez JI, Agudo-Conde C, Martinez-Salgado C, Patino-Alonso C, Rodriguez-Sanchez E, Gomez-Marcos MA, and for Vaso-risk Group.Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study.
BMC Public Health
DOI: 10.1186/1471-2458-11-266
Cardoso CC, Cabrini D, May M, Hintze M, Bhagat CS, Eleno N, Cayla C, Walther T, M Bader M.Functional expression of angiotensinogen depends on a splicing enhancers in exon 2.
Molecular and Cellular Endocrinology
DOI: 10.1016/j.mce.2010.10.016
Sánchez-González PD, López-Hernández FJ, López-Novoa JM, Morales AI.An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity.
Critical Review in Toxicology
DOI: 10.3109/10408444.2011.602662
Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez-Barriocanal F, Morales AI, Lopez-Novoa JM.Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity.
Nephrology Dialysis and Transplantation. 26: 3484-3495, 2011.
DOI: 10.1093/ndt/gfr195
Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients.
BMC Medicine
DOI: 10.1186/1741-7015-8-86
Eleno N, Düwel A, Muñoz A, Paz-Bouza J, López-Novoa JM, Lozano F.Endoglin as a marker in cervical paragangliomas.
Head and Neck
DOI: 10.1002/hed.21248
Núñez R, Sancho-Martínez SM, Novoa JM, López-Hernández FJ.Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies.
Cell Death & Differentiation 17: 1665-1671, 2010.
DOI: 10.1038/cdd.2010.96
García-Sánchez O, López-Hernández FJ, López-Novoa JM.An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease.
Kidney International
DOI: 10.1038/ki.2010.88
Empresas colaboradoras
Patentes
Colaboraciones
Con grupos de investigación Españoles
CON GRUPOS DE INVESTIGACIÓN EXTRANJEROS
aSOCIACIONES cIENTÍFICAS
ERA-EDTA: European Renal Association – European Dialysis and Transplant Association.
EUROTOX: Federation of European Toxicologists & European Societies of Toxicology.
EUSTM: European Society for the Translational Medicine.
SEN: Sociedad Española de Nefrología.
SET: Sociedad Española de Trasplante.
AETOX: Asociación Española de Toxicología.
