Group of Translational Research on Renal and Cardiovascular Diseases
We predict disease
through the use of medical criteria.
Anticipémonos a la enfermedad
con criterios de medicina de precisión.
To understand renal and cardiovascular disease in a holistic and integrated way
We have a special interest in identifying, being able to detect and improve the management of subclinical disease and, in particular, the individual risk of developing disease, as a means to predict and prevent it. To this end, we use a multidisciplinary approach that synergistically combines pre-clinical biomedical experimentation, clinical research and artificial intelligence in an international cooperative approach. Our ultimate goal is to gain pathophysiological knowledge and to develop useful products and applications for patients, working in close collaboration with the pharmaceutical and biotechnology industry.
Main projects
and lines of research
Frail Project
A New Understanding of Frailty
in Vegetative Functions. A New Opportunity to Prevent
Renal and Cardiovascular Disease.
Did you know…?
Twenty percent of the European population is over the age of 65. By the end of this century, 15% of the population will be over 80.
Inther Project
Integration of Pathophysiology and
Artificial Intelligence to Optimize
Pharmacological Treatments and
Reduce Toxicity.
Did you know…?
Fifteen percent of the adult population receives a combination of drugs that can lead to significant alterations in kidney function and
blood pressure.
Akiprev Project
Innovative Diagnostic System
Based on New Urinary Biomarkers
to Prevent and Monitor Acute Kidney Damage.
Did you know…?
Acute renal damage affects 2-3% of hospitalized patients and 10-30% of ICU patients.
We can detect the risk
of kidney damage.
Biotab Project
A different type of project:
Tobacco Also Damages Our Kidneys. Development of a Diagnostic System to Monitor Renal Damage.
Did you know…?In Spain, tobacco causes more than 50,000 deaths a year, 13% of total annual deaths.
Proyecto Akiprev
Sistema diagnóstico innovador
basado en nuevos biomarcadores
urinarios para prevenir y monitorizar el daño renal agudo.
¿Sabías que…?
El daño renal agudo afecta al 2-3% de los pacientes hospitalizados y al 10-30% de los pacientes en UCI.
Podemos detectar el riesgo
de padecer daño renal.
Proyecto Biotab
Un proyecto diferente…
El tabaco también daña los riñones. Desarrollo de un sistema diagnóstico para monitorizar el daño renal.
¿Sabías que…?
En España el tabaco provoca más de 50.000 muertes al año, el 13% del total de muertes anuales.
Predit Project
Development of an App That Predicts
the Functioning of a Transplanted Kidney.
Did you know…?
Spain is a world leader in organ transplantation.
Kidney transplants are the most frequent
(15,702 in the last 5 years).
ICItox Project
Prognosis of Cancer Patients Worsens Due to Renal Dysfunction Resulting from Treatments.
Did you know…?
The prognosis of cancer patients worsens due to renal dysfunction that treatments can cause.
CardioRen Project
Prevention and Early Detection of
Renal Damage Following
Cardiac Surgery.
Did you know…?
Major surgery is one of the most frequent causes of
renal damage.
Preverc Project
Early Diagnosis and
Preventive Treatment of
Chronic Kidney Disease.
Did you know…?
Chronic kidney disease
affects 1 in 7 adults, more
than 7.5 million people in Spain.
Proyecto CardioRen
Prevención y detección precoz del
daño renal que se produce tras la
cirugía cardiaca.
¿Sabías que…?
La cirugía mayor es una de las causas más frecuentes de daño
renal.
Proyecto Preverc
Sistema de diagnóstico temprano
y tratamiento preventivo de
la enfermedad renal crónica.
¿Sabías que…?
La enfermedad renal crónica
afecta a 1 de cada 7 adultos, más
de 7,5 millones de españoles.
Lines of Research
INTEGRATED
PATHOPHYSIOLOGY
Comprehensive approach, analysis and modelling of physiological
and pathological processes of the renal and cardiovascular systems.
PREVENTIVE AND PRECISION
DIAGNOSTICS
A new strategy for detecting the risk of developing kidney disease.
PREVENTIVE
TREATMENT
Development of therapeutics targeting the mechanisms of
disease.
RENAL
TOXICOLOGY
• Antioxidant treatments for the prevention of pharmacological nephrotoxicity.
• New diagnostic and monitoring systems for renal toxicity.
Publications
Daniel Muñoz-Reyes, Ana I. Morales, Marta Prieto. Transit and Metabolic Pathways of Quercetin in Tubular Cells: Involvement of Its Antioxidant Properties in the Kidney. Antioxidants, 2021, 10, 909. DOI: 10.3390/antiox10060909
Jose Martin-Reina, Alfredo G. Casanova, Bouchra Dahiri, Isaías Fernández, Ana Fernández-Palacín, Juan Bautista, Ana I. Morales, Isabel Moreno. Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides. International Journal of Environmental Research and Public Health 2021, 18, 5909. DOI: 10.3390/ijerph18115909
Casanova AG, Prieto M, Colino CI, Gutiérrez-Millán C, Ruszkowska-Ciastek B, de Paz E, Martín Á, Morales AI, López-Hernández FJ. A micellar formulation of quercetin prevents cisplatin nephrotoxicity. International Journal of Molecular Sciences 2021; 22: 729. DOI: 10.3390/ijms22020729
Casanova AG, Harvat M, Vicente-Vicente L, Pellicer-Valero OJ, Morales AI, López-Hernández FJ, Martín-Guerrero JD. Regression modeling of the antioxidant-to-nephroprotective action shows the pivotal role of oxidative stress in cisplatin nephrotoxicity. Antioxidants 2021; 10: 1355. DOI: 10.3390/antiox10091355
Francisco J. López Hernández. The furosemide stress test: Perspectives for acute kidney injury diagnosis. Brazilian Journal of Nephrology 2021; 43: 452-454. DOI: 10.1590/2175-8239-JBN-2021-E010
Casanova AG, López-Hernández FJ, Vicente-Vicente L, Morales AI. Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease? Antioxidants 2021; 10: 1669. DOI: 10.3390/antiox10111669
Martin WP, Chuah YHD, Conroy E, Reynolds AL, Judge C, López-Hernández FJ, le Roux CW, Docherty NG. Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury. BMJ Open Science 2021; 5: e100240. DOI: 10.1136/bmjos-2021-100240
L. Vicente-Vicente, A. G. Casanova, M. T. Hernández-Sánchez, M. Prieto, C. Martínez-Salgado, F. J. López-Hernández, I. Cruz-González, A. I. Morales. Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy. Journal of Clinical Medicine 10 (21): 4942, 2021. DOI: 10.3390/jcm10214942
A. G. Casanova, I. Fuentes-Calvo, M. T. Hernández-Sánchez, M. Quintero, P. Toral, M. T. Caballero, C. Martínez-Salgado, A. I. Morales, A. T. Layton, N. Eleno, F. J. López-Hernández. The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats. Translational Research 231: 76-91, 2021. DOI: 10.1016/j.trsl.2020.11.011
I. Fuentes-Calvo, C. Cuesta, S. M. Sancho-Martínez, O. A. Hidalgo-Thomas, M. Paniagua-Sancho, F. J. López-Hernández, C. Martínez-Salgado. Biomarkers of persistent renal vulnerability after acute kidney injury recovery. Scientific Reports 2021 11(1): 21183, 2021. DOI: 10.1038/s41598-021-00710-y
Muñoz-Félix JM, Martínez-Salgado C.Dissecting the Involvement of Ras GTPases in Kidney Fibrosis.
Genes (Basel)
DOI: 10.3390/genes12060800
López-Hernández FJ.Cell Surface Area to Volume Relationship During Apoptosis and Apoptotic Body Formation.
Cellular Physiology and Biochemistry
DOI: 10.33594/000000369
Fuentes-Calvo I, Martinez-Salgado C.Sos1 Modulates Extracellular Matrix Synthesis, Proliferation, and Migration in Fibroblasts.
Frontiers in Physiology
DOI: 10.3389/fphys.2021.645044
Casanova AG, Prieto M, Colino CI, Gutiérrez-Millán C, Ruszkowska-Ciastek B, de Paz E, Martín Á, Morales AI, López-Hernández FJ.A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity.
International Journal of Molecular Sciences
DOI: 10.3390/ijms22020729.
Paniagua-Sancho M, Quiros Y, Casanova AG, Blanco-Gozalo V, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, Sancho-Martínez SM, López-Hernández FJ.Urinary plasminogen activator inhibitor-1: A biomarker of acute tubular injury.
American Journal of Nephrology
DOI: 10.1159/000518455
Docherty NG, Delles C, D’Haese P, Layton AT, Martínez-Salgado C, Vervaet BA, López-Hernández FJ.Haemodynamic frailty-A risk factor for acute kidney injury in the elderly.
Ageing Research Reviews
DOI: 10.1016/j.arr.2021.101408
Ortega-Loubon C, Martínez-Paz P, Garcia-Moran E, Tamayo-Velasco A, López-Hernández FJ, Jorge-Monjas P, Tamayo E.Genetic susceptibility to acute kidney injury.
Journal of Clinical Medicine
DOI: 10.3390/jcm10143039
Casanova AG, Vicente-Vicente L, Hernández-Sánchez MT, Prieto M, Rihuete MI, Ramis LM, Del Barco E, Cruz JJ, Ortiz A, Cruz-González I, Martínez-Salgado C, Pescador M, López-Hernández FJ, Morales AI.Urinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterations
Biomedicine & Pharmacotherapy
DOI: 10.1016/j.biopha.2019.109684
Casanova AG, Hernández-Sánchez MT, Martínez-Salgado C, Morales AI, Vicente-Vicente L, López-Hernández FJ. A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: Implications for clinical application
Critical Reviews in Toxicology
DOI: 10.1080/10408444.2020.1837070
Prieto-Garcia L, Vicente-Vicente L, Blanco-Gozalo V, Hidalgo-Thomas O, Garcia-Macias MC, Kurtz A, Layton AT, Sanz A, Morales AI, Martinez-Salgado C, Pericacho M, Sancho-Martinez S, Lopez-Hernandez FJ. Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury.
Laboratory Investigation
DOI: 10.1038/s41374-020-0473-9
Martin WP, White J, López-Hernández FJ, Docherty NG, le Roux CW.Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease
Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.00289
Sancho-Martínez SM, Blanco-Gozalo V, Quiros Y, Prieto-García L, Montero-Gómez MJ, Docherty NG, Martínez-Salgado C, Morales AI, López-Novoa JM, López-Hernández FJ.Impaired tubular reabsorption is the main mechanism explaining increases in urinary NGAL excretion following acute kidney injury in rats
Toxicological Sciences
DOI: 10.1093/toxsci/kfaa029
García-Sánchez O, López-Novoa JM, López-Hernández FJ.Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury. Ageing Research ReviewsDOI: 10.1097/MD.0000000000001617
Sancho-Martínez SM, Sánchez-Juanes F, Blanco-Gozalo V, Fontecha-Barriuso M, Prieto-García L, Fuentes-Calvo I, González-Buitrago JM, Morales AI, Martínez-Salgado C, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Novoa JM, López-Hernández FJ.Urinary TCP1-eta: A cortical damage marker for the pathophysiological diagnosis and prognosis of acute kidney injury.
Toxicological Sciences
DOI: 10.1093/toxsci/kfz242
Sánchez-Garrido AI, Prieto-Vicente V, Blanco-Gozalo V, Arévalo M, Quiros Y, López-Montañés D, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JM.Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice.
Journal of Clinical Medicine
DOI: 10.3390/jcm8122086
Casanova AG, Hernández-Sánchez MT, López-Hernández FJ, Martínez-Salgado C, Prieto M, Vicente-Vicente L, Morales AI.Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity
European Journal of Clinical Pharmacology
DOI: 10.1007/s00228-019-02771-5
Fuentes-Calvo I, Usategui-Martín R, Calero-Paniagua I, Moledo-Pouso C, García-Ortiz L, Del Pino-Montes J, González-Sarmiento R, Martínez-Salgado C.Influence of Angiogenic Mediators and Bone Remodelling in Paget´s Disease of Bone.
International Journal of Medical Sciences
DOI: 10.7150/ijms.26580
García-Cenador B, Blanco-Gozalo, López-Montañés D, Sanz Giménez-Rico JR, López-Novoa JM, López-Hernández FJ.Cardiotrophin 1 improves kidney preservation, graft function and survival in transplanted rats
Transplantation
DOI: 10.1097/TP.0000000000002313
Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-Sánchez EM, López-Montañés D, Quirós Y, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JM.Cardiotrophin-1 attenuates experimental colitis in mice
Clinical Science
DOI: 10.1042/CS20171513
Sancho-Martínez SM, Prieto-García L, Prieto M, Fuentes-Calvo I, López-Novoa JM, Morales AI, Martínez-Salgado C, López-Hernández FJ.N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity.
Toxicology and Applied Pharmacology
DOI: 10.1016/j.taap.2018.04.010
Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Pescador M, López-Hernández FJ, Morales AI.A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity.
Toxicology
DOI: 10.1016/j.tox.2016.12.003
Prieto García L, Pericacho M, Sancho-Martínez S, Sánchez A, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.Mechanisms of Triple Whammy Acute Kidney Injury.
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2016.07.011
Quirós Y, Blanco-Gozalo V, Sanchez-Gallego JI, López-Hernández FJ, Ruiz J, Perez de Obanos MP, López-Novoa JM.Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats.
Pharmacological Research
DOI: 10.1016/j.phrs.2016.02.025
Gamella-Pozuelo L, IFuentes-Calvo I, Gómez-Marcos MA, Recio-Rodriguez JI, Agudo-Conde C, Fernández-Martín JL, Cannata-Andía JB, López-Novoa JM, García-Ortiz L, Martínez-Salgado C.Plasma cardiotrophin-1 as a marker of hypertension and diabetes-induced target organ damage and cardiovascular risk.
Medicine
DOI: 10.1097/MD.0000000000001218
Vicente-Vicente L, Sánchez-Juanes F, García-Sánchez O, Blanco-Gozalo V, Pescador M, Sevilla MA, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.
Toxicology Letters
DOI: 10.1016/j.toxlet.2014.11.033
García-Sánchez O, Sancho-Martínez SM, López-Novoa JM, López-Hernández FJ.Activation of the ALK-5 pathway is not per se sufficient for the antiproliferative effect of TGF-β on renal tubule epithelial cells.
Cellular Physiology and Biochemistry
DOI: 10.1159/000430246
Sancho-Martínez SM, Prieto-García L, Blanco-Gozalo V, Fontecha M, López-Novoa JM, López-Hernández FJ.Urinary proteomics in renal pathophysiology: Impact of proteinuria.
Proteomics Clinical Applications
DOI: 10.1002/prca.201400183
Blázquez-Medela M, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.Increased KLK9 urinary excretion is associated to hypertension-induced cardiovascular damage and renal alterations
Medicine
DOI: 10.1097/MD.0000000000001617
Muñoz-Félix M, González-Núñez M, Martínez-Salgado C, López-Novoa JM.TGF-β and BMPs inhibitors in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2015.10.003
Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ.TGF-? and BMPs inhibitors in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?HypertensionDOI: 10.3390/ijms20194961
Rodríguez-Peña A, Fuentes-Calvo I, Docherty N, Arévalo M, Grande MT, Eleno N, Pérez-Barriocanal F, López-Novoa JM.Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy.
BioMed Research International
DOI: 10.1155/2014/124902
García-Sánchez O, López-Novoa JM, López-Hernández FJ.Interferon-γ Reduces the Proliferation of Primed Human Renal Tubular Cells.
Nephron Extra
DOI: 10.1159/000353587
Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C.Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.
Kidney International
DOI: 10.1038/ki.2013.292
Gomez-Marcos MA, Gonzalez-Sarmiento R, Recio-Rodríguez JI, Agudo-Conde C, Gamella-Pozuelo L, Perretta-Tejedor N, Martínez-Salgado C, García-Ortiz L.Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case–control study protocol (LOD-Hipertensión).
BMJ Open
DOI: 10.1136/bmjopen-2014-005112
Blázquez-Medela AM, García-Sánchez O, Blanco-Gozalo V, Quiros Y, Montero MJ, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
PLoS One
DOI: 10.1371/journal.pone.0105988
Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM, Ruiz-Ortega M, Egido J, Burkly LC, Martinez-Salgado C, Ortiz A.TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.
Biochimica et Biophysica Acta-Molecular Basis of Disease
DOI: 10.1016/j.bbadis.2013.05.032
Fuentes-Calvo I, Crespo P, Santos E, López-Novoa JM, Martinez-Salgado C.The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.
Biochimica et Biophysica Acta – Molecular Cell Research
DOI: 10.1016/j.bbamcr.2013.07.008
Rossi E, Sanz-Rodriguez F, Eleno N, Düwel A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C.Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
Blood
DOI: 10.1182/blood-2012-06-435347
Ghosh S, Kapil V, Fuentes-Calvo I, Bubb K, Pearl V, Milsom A, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb W, Caulfield M, Hobbs A.Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Hypertension
DOI: 10.1161/HYPERTENSIONAHA.111.00933
Ferreira L, Fuentes-Calvo I, Muñoz-Félix JM, Muñiz C, Sánchez-Juanes F, Raposo C, González-Buitrago JM, López-Novoa JM, Martínez-Salgado C.Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.
Electrophoresis
DOI: 10.1002/elps.201100606
Sancho-Martínez SM, Prieto-García L, Prieto M, López-Novoa JM, López-Hernández FJ.Subcellular targets of cisplatin cytotoxicity: an integrated view.
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2012.07.003
López-Hernández FJ, López-Novoa JM.Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects.
Cell Tissue Research
DOI: 10.1007/s00441-011-1275-6
Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C.H-Ras isoform modulates extracellular matrix synthesis, proliferation and migration in fibroblasts.
American Journal of Physiology (Cell Physiology)
DOI: 10.1152/ajpcell.00103.2011
Garcia-Ortiz L, Ramos-Delgado E, Recio-Rodriguez JI, Agudo-Conde C, Martinez-Salgado C, Patino-Alonso C, Rodriguez-Sanchez E, Gomez-Marcos MA, and for Vaso-risk Group.Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study.
BMC Public Health
DOI: 10.1186/1471-2458-11-266
Cardoso CC, Cabrini D, May M, Hintze M, Bhagat CS, Eleno N, Cayla C, Walther T, M Bader M.Functional expression of angiotensinogen depends on a splicing enhancers in exon 2.
Molecular and Cellular Endocrinology
DOI: 10.1016/j.mce.2010.10.016
Sánchez-González PD, López-Hernández FJ, López-Novoa JM, Morales AI.An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity.
Critical Review in Toxicology
DOI: 10.3109/10408444.2011.602662
Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez-Barriocanal F, Morales AI, Lopez-Novoa JM.Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity.
Nephrology Dialysis and Transplantation. 26: 3484-3495, 2011.
DOI: 10.1093/ndt/gfr195
Sancho-Martínez SM, Piedrafita FJ, Cannata-Andía JB, López-Novoa JM, López-Hernández FJ.Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis.
Toxicological Sciences
DOI: 10.1093/toxsci/kfr098
Sánchez-González PD, López-Hernandez FJ, Morales AI, Macías-Nuñez JF, López-Novoa JM.Effects of deferasirox on renal function and renal epithelial cell death.
Toxicological Letters
DOI: 10.1016/j.toxlet.2011.03.018
López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López Hernández FJ.Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.
Journal of Translational Medicine
DOI: 10.1186/1479-5876-9-13
Ferreira L, Quiros Y, Sancho-Martínez SM, García-Sánchez O, Raposo C, López-Novoa JM, González-Buitrago JM, López-Hernández FJ.Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.
Kidney International
DOI: 10.1038/ki.2010.439
Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ.New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view.
Kidney International
DOI: 10.1038/ki.2010.337
Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arévalo M, Leverve X, López-Novoa JM, El-Mir MY.Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.
Kidney International
DOI: 10.1038/ki.2010.11
Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients.
BMC Medicine
DOI: 10.1186/1741-7015-8-86
Eleno N, Düwel A, Muñoz A, Paz-Bouza J, López-Novoa JM, Lozano F.Endoglin as a marker in cervical paragangliomas.
Head and Neck
DOI: 10.1002/hed.21248
Núñez R, Sancho-Martínez SM, Novoa JM, López-Hernández FJ.Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies.
Cell Death & Differentiation 17: 1665-1671, 2010.
DOI: 10.1038/cdd.2010.96
García-Sánchez O, López-Hernández FJ, López-Novoa JM.An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease.
Kidney International
DOI: 10.1038/ki.2010.88
Mollinedo F, Gajate C, Morales AI, del Canto-Jañez E, Justies N, Collía F, Rivas JV, Modolell M, Iglesias A.Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.108.148254
Collaborating Companies
Patents
Collaborations
With Spanish research groups
WITH FOREIGN RESEARCH GROUPS
NETWORKS AND CONSORTIA
RedinRen: Spanish Renal Research Network of the Carlos III Health Institute (RETICS RD16/0009/0025).
DisMOD: European Consortium of leading research groups, companies, consultants and patient associations with synergistic capabilities, joining efforts on a multidisciplinary
and bench-to-bed strategy for preventive and personalized
medicine, and integral treatment.
SCIENTIFIC ASSOCIATIONS
ERA-EDTA: European Renal Association – European Dialysis and Transplant Association.
EUROTOX: Federation of European Toxicologists & European Societies of Toxicology.
EUSTM: European Society for the Translational Medicine.
SEN: Spanish Society of Nephrology.
SET: Spanish Society of Transplantation.
AETOX: Spanish Association of Toxicology.