+34 923 294 500 Ext. 1444, 1945 y 1862  trecardgroup@gmail.com

Grupo de Investigación Traslacional en
Enfermedades Renales y Cardiovasculares

We predict disease
through the use of medical criteria.

Anticipémonos a la enfermedad

con criterios de medicina de precisión.

To understand renal and cardiovascular disease in a holistic and integrated way

We have a special interest in identifying, being able to detect and improve the management of subclinical disease and, in particular, the individual risk of developing disease, as a means to predict and prevent it. To this end, we use a multidisciplinary approach that synergistically combines pre-clinical biomedical experimentation, clinical research and artificial intelligence in an international cooperative approach. Our ultimate goal is to gain pathophysiological knowledge and to develop useful products and applications for patients, working in close collaboration with the pharmaceutical and biotechnology industry.

Main projects
and lines of research

Frail Project

A New Understanding of Frailty
in Vegetative Functions. A New Opportunity to Prevent
Renal and Cardiovascular Disease.

Did you know…?

Twenty percent of the European population is over the age of 65. By the end of this century, 15% of the population will be over 80.

Inther Project

Integration of Pathophysiology and
Artificial Intelligence to Optimize
Pharmacological Treatments and
Reduce Toxicity.

Did you know…?

Fifteen percent of the adult population receives a combination of drugs that can lead to significant alterations in kidney function and
blood pressure.

Akiprev Project

Innovative Diagnostic System
Based on New Urinary Biomarkers
to Prevent and Monitor Acute Kidney Damage.

Did you know…?

Acute renal damage affects 2-3% of hospitalized patients and 10-30% of ICU patients.
We can detect the risk
of kidney damage.

Biotab Project

A different type of project:
Tobacco Also Damages Our Kidneys. Development of a Diagnostic System to Monitor Renal Damage.

Did you know…?
In Spain, tobacco causes more than 50,000 deaths a year, 13% of total annual deaths.

Proyecto Akiprev

Sistema diagnóstico innovador
basado en nuevos biomarcadores
urinarios para prevenir y monitorizar el daño renal agudo.

¿Sabías que…?

El daño renal agudo afecta al 2-3% de los pacientes hospitalizados y al 10-30% de los pacientes en UCI.
Podemos detectar el riesgo
de padecer daño renal.

Proyecto Biotab

Un proyecto diferente…

El tabaco también daña los riñones. Desarrollo de un sistema diagnóstico para monitorizar el daño renal.

¿Sabías que…?

En España el tabaco provoca más de 50.000 muertes al año, el 13% del total de muertes anuales.

Predit Project

Development of an App That Predicts
the Functioning of a Transplanted Kidney.

Did you know…?

Spain is a world leader in organ transplantation.
Kidney transplants are the most frequent
(15,702 in the last 5 years).

ICItox Project

Prognosis of Cancer Patients Worsens Due to Renal Dysfunction Resulting from Treatments.

Did you know…?

The prognosis of cancer patients worsens due to renal dysfunction that treatments can cause.

CardioRen Project

Prevention and Early Detection of
Renal Damage Following
Cardiac Surgery.

Did you know…?

Major surgery is one of the most frequent causes of
renal damage.

Preverc Project

Early Diagnosis and
Preventive Treatment of
Chronic Kidney Disease.

Did you know…?

Chronic kidney disease
affects 1 in 7 adults, more
than 7.5 million people in Spain.

Proyecto CardioRen

Prevención y detección precoz del
daño renal que se produce tras la
cirugía cardiaca.

¿Sabías que…?

La cirugía mayor es una de las causas más frecuentes de daño

Proyecto Preverc

Sistema de diagnóstico temprano
y tratamiento preventivo de
la enfermedad renal crónica.

¿Sabías que…?

La enfermedad renal crónica
afecta a 1 de cada 7 adultos, más
de 7,5 millones de españoles.

Lines of Research


Comprehensive approach, analysis and modelling of physiological
and pathological processes of the renal and cardiovascular systems.

  • Acute renal damage
  • Chronic kidney disease
  • Hypertension, diabetes,


A new strategy for detecting the risk of developing kidney disease.

  • Urinary biomarkers
  • Intelligent computer systems
  • Clinical decision support systems


Development of therapeutics targeting the mechanisms of

  • Drug repositioning
  • Development of dietary supplements


• Antioxidant treatments for the prevention of pharmacological nephrotoxicity.

• New diagnostic and monitoring systems for renal toxicity.


Casanova AG, Fuentes-Calvo I, Hernández-Sánchez MT, Quintero M, Toral P, Caballero MT, Martínez-Salgado C, Morales AI, Layton AT, Eleno N, López-Hernández FJ.The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats.
Translational Research
DOI: 10.1016/j.trsl.2020.11.011.

Muñoz-Reyes D, Morales AI, Prieto M. Transit and Metabolic Pathways of Quercetin in Tubular Cells: Involvement of Its Antioxidant Properties in the Kidney. Antioxidant, 10, 909.

Martin WP, Chuah YHD, Conroy E, Reynolds AL, Judge C, López-Hernández FJ, le Roux CW, Docherty NG. Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury. BMJ Open Sci. 2021; 5: e100240. doi: 10.1136/bmjos-2021-100240.

Casanova AG, López-Hernández FJ, Vicente-Vicente L, Morales AI. Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease? Antioxidants. 2021; 10: 1669. doi: 10.3390/antiox10111669.

Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Prieto M, Martínez-Salgado C, López-Hernández FJ *, Cruz-González I, Morales AI. Albuminuria pre-emptively identifies cardiac patients at risk of contrast-induced nephropathy. J Clin Med. 2021; 10: 4942. doi: 10.3390/jcm10214942.

Fuentes-Calvo I, Cuesta C, Sancho-Martíneza SM, Hidalgo-Thomas OA, Paniagua-Sancho M, López-Hernández FJ, Martínez-Salgado C. Biomarkers of persistent renal vulnerability after acute kidney injury recovery. Sci Rep. 2021; 11: 21183. doi: 10.1038/s41598-021-00710-y.

Casanova AG, Harvat M, Vicente-Vicente L, Pellicer-Valero OJ, Morales AI, López-Hernández FJ, Martín-Guerrero JD. Regression modeling of the antioxidant-to-nephroprotective action shows the pivotal role of oxidative stress in cisplatin nephrotoxicity. Antioxidants. 2021; 10: 1355. doi: 10.3390/antiox10091355.

Sancho-Martínez SM, Blanco-Gozalo V, Quiros Y, Prieto-García L, Montero-Gómez MJ, Docherty NG, Martínez-Salgado C, Morales AI, López-Novoa JM, López-Hernández FJ.Impaired tubular reabsorption is the main mechanism explaining increases in urinary NGAL excretion following acute kidney injury in rats
Toxicological Sciences
DOI: 10.1093/toxsci/kfaa029

Martin WP, White J, López-Hernández FJ, Docherty NG, le Roux CW.Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease
Frontiers in Endocrinology
DOI: 10.3389/fendo.2020.00289

Garzón-Martínez M, Perretta-Tejedor N, Garcia-Ortiz L, Gomez-Marcos M, Gonzalez-Sarmiento R, Lopez-Hernandez F, Martinez-Salgado C.Association of alk1 and endoglin polymorphisms with cardiovascular damage.
Scientific Reports
DOI: 10.1038/s41598-020-66238-9

Blanco-Gozalo V, Casanova AG, Sancho-Martínez SM, Prieto M, Quiros Y, Morales AI, Martínez-Salgado C, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Hernández FJ.Combined use of GM2AP and TCP1-eta urinary levels predicts recovery from intrinsic acute kidney injury
Scientific Reports
DOI: 10.1038/s41598-020-68398-0

Prieto M, Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Gomez-Marcos MA, Garcia-Ortiz L, Morales AI.Designing new diagnostic systems for the early detection of tobacco-associated chronic renal damage in patients of a primary care centre in Salamanca, Spain: an observational, prospective study protocol
BMJ Open
DOI: 10.1136/bmjopen-2019-032918

Arcidiacono MV, Carrillo-López N, Panizo S, Castro-Grattoni AL, Valcheva P, Ulloa C, Rodríguez-Carrio J, Cardús A, Quirós-Caso C, Martínez-Arias L, Martínez-Salgado C, Motilva MJ, Rodriguez-Suarez C, Cannata-Andía JB, Dusso AS.Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.
Scientific Reports
DOI: 10.1038/s41598-019-54306-8

Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.
Acta Physiologica
DOI: 10.1111/apha.13247

Vicente-Vicente L, González-Calle D, Casanova AG, Hernández-Sánchez MT, Prieto M, Rama-Merchán JC, Martín-Moreiras J, Martín-Herrero F, Sánchez PL, López-Hernández FJ, Cruz-González I and Morales AI.Quercetin, a Promising Clinical Candidate for The Prevention of Contrast-Induced Nephropathy
International Journal of Molecular Sciences
DOI: 10.3390/ijms20194961

Fuentes-Calvo I, Usategui-Martín R, Calero-Paniagua I, Moledo-Pouso C, García-Ortiz L, Del Pino-Montes J, González-Sarmiento R, Martínez-Salgado C.Influence of Angiogenic Mediators and Bone Remodelling in Paget´s Disease of Bone.
International Journal of Medical Sciences
DOI: 10.7150/ijms.26580

García-Cenador B, Blanco-Gozalo, López-Montañés D, Sanz Giménez-Rico JR, López-Novoa JM, López-Hernández FJ.Cardiotrophin 1 improves kidney preservation, graft function and survival in transplanted rats
DOI: 10.1097/TP.0000000000002313

Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-Sánchez EM, López-Montañés D, Quirós Y, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JM.Cardiotrophin-1 attenuates experimental colitis in mice
Clinical Science
DOI: 10.1042/CS20171513

Sancho-Martínez SM, Prieto-García L, Prieto M, Fuentes-Calvo I, López-Novoa JM, Morales AI, Martínez-Salgado C, López-Hernández FJ.N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity.
Toxicology and Applied Pharmacology
DOI: 10.1016/j.taap.2018.04.010

Martin-Sanchez D, Gallegos-Villalobos A, Fontecha-Barriuso M, Carrasco S, Sanchez-Niño MD, Lopez-Hernandez FJ, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB.Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells
Scientific Reports
DOI: 10.1038/srep41510

Perretta-Tejedor N, Fernández-Mateos J, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Agudo-Conde C, Rodriguez-Sánchez E, Morales AI, López-Hernández FJ, López-Novoa JM, González-Sarmiento R, Martínez-Salgado C.Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.
Scientific Report
DOI: 10.1038/srep41875

Sánchez-González PD, López-Hernández FJ, Dueñas M, Prieto M, Sánchez-López E, Thomale J, Ruiz-Ortega M, López-Novoa JM, Morales AI.Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues.
Food and Chemical Toxicology
DOI: 10.1016/j.fct.2017.06.047

Casanova AG, Vicente-Vicente L, Hernández-Sánchez MT, Pescador M, Prieto M, Martínez-Salgado C, Morales AI, López-Hernández FJ.Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-tonephroprotective correlation.
DOI: 10.1016/j.tox.2017.04.015

Muñoz-Félix JM, Fuentes-Calvo I, Cuesta C, Eleno N, Crespo P, López-Novoa JM, Martínez-Salgado C.Absence of K-Ras reduces proliferation and migration but increases extracellular matrix synthesis in fibroblasts.
Journal of Cell Physiology
DOI: 10.1002/jcp.25340

Quirós-González I, Román-García P, Alonso-Montes C, Barrio-Vázquez S, Carrillo-López N, Naves-Díaz M, Mora MI, Corrales FJ, López-Hernández FJ, Ruiz-Torres MP, Cannata-Andía JB, Fernández-Martín JL.Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load
DOI: 10.1016/j.bone.2016.01.005

Muñoz-Félix JM, Cuesta C, Perretta-Tejedor N, Subileau M, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro.
Cellular Signalling
DOI: 10.1016/j.cellsig.2016.05.015

Muñoz-Félix JM, Perretta-Tejedor N, Eleno N, López-Novoa JM, Martínez-Salgado C.ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts.
Biochimica et Biophysica Acta – Molecular Cell Research
DOI: 10.1016/j.bbamcr.2014.02.017

Oujo B, Muñoz-Félix JM, Arévalo M, Núñez-Gómez E, Pérez-Roque L, Pericacho M, González-Núñez M, Langa C, Martínez-Salgado C, Perez-Barriocanal F, Bernabeu C, Lopez-Novoa JM.L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction.
PLoS One
DOI: 10.1371/journal.pone.0110365

Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin G.Stomatin-domain protein interactions with acid sensing ion channels modulate nociceptor mechanosensitivity.
Journal of Physiology
DOI: 10.1113/jphysiol.2013.261180

Rossi E, Sanz-Rodriguez F, Eleno N, Düwel A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C.Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
DOI: 10.1182/blood-2012-06-435347

Vicente-Vicente L, Ferreira L, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.Increased urinary excretion of albumin, hemopexin, transferrin and VDBP correlates with chronic sensitization to gentamicin nephrotoxicity in rats.
DOI: 10.1016/j.tox.2012.12.006

Quiros Y, Sánchez-González PD, López-Hernández FJ, Morales AI, López-Novoa JM.Cardiotrophin-1 administration prevents the renal toxicity of iodinated contrast media in rats.
Toxicological Science
DOI: 10.1093/toxsci/kft007

Fernandes-Cerqueira C, Sampaio-Maia B, Quelhas-Santos J, Moreira-Rodrigues M, Simoes-Silva L, Blazquez-Medela AM, Martinez-Salgado C, Lopez-Novoa JM, Pestana M.Concerted action of ANP and dopamine D1 receptor to regulate sodium homeostasis in puromycin aminonucleoside-induced nephrotic syndrome.
Biomed Research International
DOI: 10.1155/2013/397391

Cabezas-Rodriguez I, Carrero JJ, Zoccali C, Qureshi AR, Ketteler M, Floege J, London G, Locatelli F, Gorriz JL, Rutkowski B, Memmos D, Ferreira A, Covic A, Teplan V, Bos WJ, Kramar R, Pavlovic D, Goldsmith D, Nagy J, Benedik M, Verbeelen D, Tielemans C, Wuthrich RP, Martin PY, Martinez-Salgado C, Fernandez-Martin JL, Cannata-Andia JB.Influence of Body Mass Index on the Association of Weight Changes with Mortality in Hemodialysis Patients.
Clinical Journal of the American Society of Nephrology
DOI: 10.2215/CJN.10951012

Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodriguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.Osteoprotegerin Is Associated To Cardiovascular Risk In Hypertension And/Or Diabetes.
European Journal of Clinical Investigation
DOI: 10.1111/j.1365-2362.2011.02619.x

García-Ortiz L, Recio-Rodríguez JI, Parra-Sanchez J, González-Elena LJ, Patino-Alonso MC, Agudo-Conde C, Rodríguez-Sánchez E, Gómez-Marcos MA; Vaso-risk group.A new tool to assess retinal vessel caliber. Reliability and validity of measures and their relationship with cardiovascular risk.
Journal of Hypertension
DOI: 10.1097/HJH.0b013e3283506628

Recio-Rodriguez JI, Gomez-Marcos MA, Patino-Alonso MC, Agudo-Conde C, Rodriguez-Sanchez E, Garcia-Ortiz L; Vasorisk group.Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive.
BMC Cardiovascular Disorders.
DOI: 10.1186/1471-2261-12-3

García-García A, Gómez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, Rodríguez-Sánchez E, Agudo-Conde C, García-Ortiz L; Vaso-risk group.Office and 24-hour heart rate and target organ damage in hypertensive patients.
BMC Cardiovascular Disorders
DOI: 10.1186/1471-2261-12-19

López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López Hernández FJ.Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.
Journal of Translational Medicine
DOI: 10.1186/1479-5876-9-13

Quiros Y, Vicente-Vicente L, Morales AI, López-Novoa JM, López-Hernández FJ.An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin.
Toxicological Sciences
DOI: 10.1093/toxsci/kfq267

Blázquez-Medela AM, López-Novoa JM, Martínez-Salgado C.Osteoprotegerin and diabetes-associated pathologies.
Current Molecular Medicine
DOI: 10.2174/156652411795976565

Fuentes-Calvo I, Blázquez-Medela AM, Santos E, López-Novoa JM, Martínez-Salgado C.Analysis of K-ras nuclear expression in fibroblasts and mesangial cells.
PLoS One
DOI: 10.1371/journal.pone.0008703

Vicente-Vicente L, Quiros Y, Pérez-Barriocanal F, López-Novoa JM, López-Hernández FJ, Morales AI.Nephrotoxicity of uranium: pathophysiological, diagnostic and therapeutic perspectives.
Toxicological Sciences
DOI: 10.1093/toxsci/kfq178

López-Novoa JM, Martínez-Salgado C, Rodríguez-Peña AB, López Hernández FJ.Common pathophysiological mechanisms of chronic kidney diseases: therapeutic perspectivas.
Pharmacology & Therapeutics
DOI: 10.1016/j.pharmthera.2010.05.006

Gómez-Marcos MA, Martínez-Salgado C, Grandes G, Recio-Rodriguez JI, Castaño Sánchez Y, Rodríguez-Sánchez E, García-Ortiz L.Lesión orgánica subclínica y nefropatía en hipertensos de nuevo diagnóstico.
Medicina Clínica
DOI: 10.1016/j.medcli.2009.06.068

Grande MT, Fuentes-Calvo I, Arévalo M, Heredia F, Santos E, Martínez-Salgado C, Rodríguez-Puyol D, Nieto MA, López-Novoa JM.Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.
Kidney International
DOI: 10.1038/ki.2009.498

Blázquez-Medela AM, López-Novoa JM, Martínez-Salgado C.Mechanisms involved in the genesis of diabetic nephropathy.
Current Diabetes Reviews
DOI: 10.2174/157339910790909422

Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Novoa JM, López-Hernández FJ.Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.
Kidney International
DOI: 10.1038/ki.2010.267

Mollinedo F, Gajate C, Morales AI, del Canto-Jañez E, Justies N, Collía F, Rivas JV, Modolell M, Iglesias A.Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.108.148254

Collaborating Companies


P201031407. Fecha de solicitud: 22 de septiembre de 2010. Título: “Método para la detección de daño renal”.
Inventores: Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Hernández FJ, López-Novoa JM. Titular: Universidad de Salamanca.
P201130914. Fecha de solicitud: 02 junio 2011. Título: “Método para la detección de la predisposición crónica al daño renal agudo”.
Inventores: Vicente-Vicente L, Ferreira L, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI. Titular: Universidad de Salamanca.
P200930559. Fecha de solicitud: 04 de agosto de 2009. Título: “Método para la detección de daño renal”.
Inventores: Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Hernández FJ, López-Novoa JM. Titular: Universidad de Salamanca.
Submission number: 583616. PCT Application number: PCT/EP2009/056381. Filing Date: 26 May 2009. Title: “Urinary GM2 Activator Protein as a Marker of Acute Renal Failure or the Risk of Developing Acute Renal Failure”.
Inventores: Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Hernández FJ, López-Novoa JM. Titular: Universidad de Salamanca.
PCT/EP2020/063037. Fecha de prioridad: 11/05/2020. Título: “Method for the diagnosis and prognosis of acute kidney injury”.
Titular: IBSAL-IECSCYL y Universidad de Salamanca. Inventores: Sandra M. Sancho Martínez and Francisco J. López-Hernández.
EP18382975. Fecha de prioridad: 21-12-2018. Título “Combination therapy for treatment of cáncer”.
Titular: Plus Vitech S.L. Inventores del IBSAL: Yaremi Quiros Luis y Francisco J. López-Hernández.


With Spanish research groups



ERA-EDTA: European Renal Association – European Dialysis and Transplant Association.

EUROTOX: Federation of European Toxicologists & European Societies of Toxicology.

EUSTM: European Society for the Translational Medicine.

SEN: Spanish Society of Nephrology.

SET: Spanish Society of Transplantation.

AETOX: Spanish Association of Toxicology.