Science - Grupo de Investigación Traslacional en Enfermedades Renales y Cardiovasculares

We predict disease
through the use of medical criteria.

Anticipémonos a la enfermedad

con criterios de medicina de precisión.

To understand renal and cardiovascular disease in a holistic and integrated way

We have a special interest in identifying, being able to detect and improve the management of subclinical disease and, in particular, the individual risk of developing disease, as a means to predict and prevent it. To this end, we use a multidisciplinary approach that synergistically combines pre-clinical biomedical experimentation, clinical research and artificial intelligence in an international cooperative approach. Our ultimate goal is to gain pathophysiological knowledge and to develop useful products and applications for patients, working in close collaboration with the pharmaceutical and biotechnology industry.

Main projects
and lines of research

Frail Project

A New Understanding of Frailty
in Vegetative Functions. A New Opportunity to Prevent
Renal and Cardiovascular Disease.

Did you know…?

Twenty percent of the European population is over the age of 65. By the end of this century, 15% of the population will be over 80.

Inther Project

Integration of Pathophysiology and
Artificial Intelligence to Optimize
Pharmacological Treatments and
Reduce Toxicity.

Did you know…?

Fifteen percent of the adult population receives a combination of drugs that can lead to significant alterations in kidney function and
blood pressure.

Akiprev Project

Innovative Diagnostic System
Based on New Urinary Biomarkers
to Prevent and Monitor Acute Kidney Damage.

Did you know…?

Acute renal damage affects 2-3% of hospitalized patients and 10-30% of ICU patients.
We can detect the risk
of kidney damage.

Biotab Project

A different type of project:
Tobacco Also Damages Our Kidneys. Development of a Diagnostic System to Monitor Renal Damage.

Did you know…?
In Spain, tobacco causes more than 50,000 deaths a year, 13% of total annual deaths.

Proyecto Akiprev

Sistema diagnóstico innovador
basado en nuevos biomarcadores
urinarios para prevenir y monitorizar el daño renal agudo.

¿Sabías que…?

El daño renal agudo afecta al 2-3% de los pacientes hospitalizados y al 10-30% de los pacientes en UCI.
Podemos detectar el riesgo
de padecer daño renal.

Proyecto Biotab

Un proyecto diferente…

El tabaco también daña los riñones. Desarrollo de un sistema diagnóstico para monitorizar el daño renal.

¿Sabías que…?

En España el tabaco provoca más de 50.000 muertes al año, el 13% del total de muertes anuales.

Predit Project

Development of an App That Predicts
the Functioning of a Transplanted Kidney.

Did you know…?

Spain is a world leader in organ transplantation.
Kidney transplants are the most frequent
(15,702 in the last 5 years).

ICItox Project

Prognosis of Cancer Patients Worsens Due to Renal Dysfunction Resulting from Treatments.

Did you know…?

The prognosis of cancer patients worsens due to renal dysfunction that treatments can cause.

CardioRen Project

Prevention and Early Detection of
Renal Damage Following
Cardiac Surgery.

Did you know…?

Major surgery is one of the most frequent causes of
renal damage.

Preverc Project

Early Diagnosis and
Preventive Treatment of
Chronic Kidney Disease.

Did you know…?

Chronic kidney disease
affects 1 in 7 adults, more
than 7.5 million people in Spain.

Proyecto CardioRen

Prevención y detección precoz del
daño renal que se produce tras la
cirugía cardiaca.

¿Sabías que…?

La cirugía mayor es una de las causas más frecuentes de daño
renal.

Proyecto Preverc

Sistema de diagnóstico temprano
y tratamiento preventivo de
la enfermedad renal crónica.

¿Sabías que…?

La enfermedad renal crónica
afecta a 1 de cada 7 adultos, más
de 7,5 millones de españoles.

Lines of Research

INTEGRATED
PATHOPHYSIOLOGY

Comprehensive approach, analysis and modelling of physiological
and pathological processes of the renal and cardiovascular systems.

Acute renal damage
Chronic kidney disease
Hypertension, diabetes,
aging

PREVENTIVE AND PRECISION
DIAGNOSTICS

A new strategy for detecting the risk of developing kidney disease.

Urinary biomarkers
Intelligent computer systems
Clinical decision support systems

PREVENTIVE
TREATMENT

Development of therapeutics targeting the mechanisms of
disease.

Drug repositioning
Development of dietary supplements

RENAL
TOXICOLOGY

• Antioxidant treatments for the prevention of pharmacological nephrotoxicity.

• New diagnostic and monitoring systems for renal toxicity.

Publications

2021

García-García A, Gómez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, Rodríguez-Sánchez E, Agudo-Conde C, García-Ortiz L; Vaso-risk group.Urinary plasminogen activator inhibitor-1: A biomarker of acute tubular injury.Pharmacology & TherapeuticsDOI: 10.1159/000518455

Sancho-Martínez SM, Prieto-García L, Prieto M, López-Novoa JM, López-Hernández FJ.Dissecting the Involvement of Ras GTPases in Kidney Fibrosis.Pharmacological ResearchDOI: 10.1038/s41374-020-0473-9

López-Hernández FJ, López-Novoa JM.A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity.Cellular SignallingDOI: 10.1097/TP.0000000000002313

Docherty NG, Delles C, DHaese P, Layton AT, Martínez-Salgado C, Vervaet BA, López-Hernández FJ.The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats.Journal of Clinical MedicineDOI: 10.1016/j.fct.2017.06.047

Arcidiacono MV, Carrillo-López N, Panizo S, Castro-Grattoni AL, Valcheva P, Ulloa C, Rodríguez-Carrio J, Cardús A, Quirós-Caso C, Martínez-Arias L, Martínez-Salgado C, Motilva MJ, Rodriguez-Suarez C, Cannata-Andía JB, Dusso ASGenetic susceptibility to acute kidney injury.BoneDOI: 10.3390/ijms22020729.

Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado CSos1 Modulates Extracellular Matrix Synthesis, Proliferation, and Migration in Fibroblasts.Journal of Cell PhysiologyDOI: 10.3390/jcm8122086

López-Hernández, FJ. Cell surface area to volume relationship during apoptosis and apoptotic body formation. Cell Physiol Bichem. 2021; 55: 161-170. doi: 10.33594/00000036.

Docherty NG, Delles C, D’Haese P, Layton AT, Martínez-Salgado C, Vervaet BA, López-Hernández FJ. Haemodynamic frailty-A risk factor for acute kidney injury in the elderly. Ageing Res Rev. 2021; 70: 101408. doi: 10.1016/j.arr.2021.101408.

Paniagua-Sancho M, Quiros Y, Casanova AG, Blanco-Gozalo V, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, Sancho-Martínez SM, López-Hernández FJ. Urinary plasminogen activator inhibitor-1: A biomarker of acute tubular injury. Am J Nephrol. 2021. 52: 714–724 doi: 10.1159/000518455.

Casanova AG, Harvat M, Vicente-Vicente L, Pellicer-Valero OJ, Morales AI, López-Hernández FJ, Martín-Guerrero JD. Regression modeling of the antioxidant-to-nephroprotective action shows the pivotal role of oxidative stress in cisplatin nephrotoxicity. Antioxidants. 2021; 10: 1355. doi: 10.3390/antiox10091355.

Francisco J. López Hernández. The furosemide stress test: Perspectives for acute kidney injury diagnosis. Braz J Nephrol. 2021; 43: 452-454. doi: 10.1590/2175-8239-JBN-2021-E010.

Fuentes-Calvo I, Cuesta C, Sancho-Martíneza SM, Hidalgo-Thomas OA, Paniagua-Sancho M, López-Hernández FJ, Martínez-Salgado C. Biomarkers of persistent renal vulnerability after acute kidney injury recovery. Sci Rep. 2021; 11: 21183. doi: 10.1038/s41598-021-00710-y.

Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Prieto M, Martínez-Salgado C, López-Hernández FJ *, Cruz-González I, Morales AI. Albuminuria pre-emptively identifies cardiac patients at risk of contrast-induced nephropathy. J Clin Med. 2021; 10: 4942. doi: 10.3390/jcm10214942.

Casanova AG, López-Hernández FJ, Vicente-Vicente L, Morales AI. Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease? Antioxidants. 2021; 10: 1669. doi: 10.3390/antiox10111669.

Martin WP, Chuah YHD, Conroy E, Reynolds AL, Judge C, López-Hernández FJ, le Roux CW, Docherty NG. Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury. BMJ Open Sci. 2021; 5: e100240. doi: 10.1136/bmjos-2021-100240.

Muñoz-Reyes D, Morales AI, Prieto M. Transit and Metabolic Pathways of Quercetin in Tubular Cells: Involvement of Its Antioxidant Properties in the Kidney. Antioxidant, 10, 909.

Muñoz-Félix JM, Martínez-Salgado C.

Dissecting the involvement of Ras GTPases in kidney fibrosis. Genes 12: 800, 2021. IF: 3.759, Q2. doi:

Paniagua-Sancho M, Quiros Y, Casanova AG, Blanco-Gozalo V, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, Sancho-Martínez SM, López-Hernández FJ.
Urinary plasminogen activator inhibitor-1:
A Biomarker of acutetubular injury.
American Journal of Nephrology
DOI: 10.1159/000518455

2020

López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López-Hernández FJ.A meta-analysis of preclinical studies using antioxidants for the prevention of cisplatin nephrotoxicity: Implications for clinical applicationProteomics Clinical ApplicationsDOI: 10.1002/jcp.25340

García-Sánchez O, López-Novoa JM, López-Hernández FJ.Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury. Ageing Research ReviewsDOI: 10.1097/MD.0000000000001617

Laura Vicente-Vicente , David González-Calle, Alfredo Ginés Casanova, María Teresa Hernández-Sánchez, Marta Prieto , Juan Carlos Rama-Merchán , Javier Martín-Moreiras , Francisco Martín-Herrero, Pedro Luis Sánchez, Francisco J. López-Hernández, Ignacio Cruz-González and Ana Isabel MoralesImpaired tubular reabsorption is the main mechanism explaining increases in urinary NGAL excretion following acute kidney injury in ratsMedicineDOI: 10.1182/blood-2012-06-435347

Sánchez-Garrido AI, Prieto-Vicente V, Blanco-Gozalo V, Arévalo M, Quiros Y, López-Montañés D, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JMUrinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterationsCellular Physiology and BiochemistryDOI: 10.1038/srep41510

Prieto M, Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Gomez-Marcos MA, Garcia-Ortiz L, Morales AI

Designing new diagnostic systems for the early detection of tobacco-associated chronic renal damage in patients of a primary care centre in Salamanca, Spain: an observational, prospective study protocol

BMJ Open. 2020; 10:e032918. Doi: 10.1136/bmjopen-2019-032918

Sancho-Martínez SM, Sánchez-Juanes F, Blanco-Gozalo V, Fontecha-Barriuso M, Prieto-García L, Fuentes-Calvo I, González-Buitrago JM, Morales AI, Martínez-Salgado C, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Novoa JM, López-Hernández FJ. Urinary TCP1-eta: A cortical damage marker for the pathophysiological diagnosis and prognosis of acute kidney injury. Toxicol Sci. 2020; 174: 3-15. doi: 10.1093/toxsci/kfz242.

Casanova AG, Hernández-Sánchez MT, López-Hernández FJ, Martínez-Salgado C, Prieto M, Vicente-Vicente L, Morales AI. Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity. European Journal of Clinical Pharmacology. 2020; 76: 23-33. doi: 10.1007/s00228-019-02771-5.

Martin WP, White J, López-Hernández FJ, Docherty NG, le Roux CW. Metabolic Surgery to Treat Obesity in Diabetic Kidney Disease, Chronic Kidney Disease, and End-Stage Kidney Disease; What Are the Unanswered Questions? Frontiers in Endocrinology. 2020; 11:289. doi: 10.3389/fendo.2020.00289.

Garzón-Martínez M, Perretta-Tejedor N, Garcia-Ortiz L, Gomez-Marcos M, Gonzalez-Sarmiento R, Lopez-Hernandez F, Martinez-Salgado C. Association of alk1 and endoglin polymorphisms with cardiovascular damage. Sci Rep. 2020; 10: 9383. doi: 10.1038/s41598-020-66238-9.

Blanco-Gozalo V, Casanova AG, Sancho-Martínez SM, Prieto M, Quiros Y, Morales AI, Martínez-Salgado C, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Hernández FJ. Combined use of GM2AP and TCP1-eta urinary levels predicts recovery from intrinsic acute kidney injury. Sci Rep. 2020; 10: 11599. doi: 10.1038/s41598-020-68398-0.

2019

Cardoso CC, Cabrini D, May M, Hintze M, Bhagat CS, Eleno N, Cayla C, Walther T, M Bader M.Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice.Biochimica et Biophysica Acta Molecular Cell ResearchDOI: 10.3109/10408444.2011.602662

Sánchez-González PD, López-Hernández FJ, López-Novoa JM, Morales AI.Urinary TCP1-eta: A cortical damage marker for the pathophysiological diagnosis and prognosis of acute kidney injury.PLoS OneDOI: 10.1016/j.medcli.2009.06.068

Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM, Ruiz-Ortega M, Egido J, Burkly LC, Martinez-Salgado C, Ortiz A.Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.Genes (Basel)DOI: 10.1186/1471-2261-12-3

Sancho-Martínez SM, Sánchez-Juanes F, Blanco-Gozalo V, Fontecha-Barriuso M, Prieto-García L, Fuentes-Calvo I, González-Buitrago JM, Morales AI, Martínez-Salgado C, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Novoa JM, López-Hernández FJ.Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease. Kidney InternationalDOI: 10.1186/1479-5876-9-13

García-Cenador B, Blanco-Gozalo, López-Montañés D, Sanz Giménez-Rico JR, López-Novoa JM, López-Hernández FJQuercetin, a Promising Clinical Candidate for The Prevention of Contrast-Induced NephropathyBMJ OpenDOI: 10.1038/ki.2010.11

Muñoz-Félix JM, Martínez-Salgado C.Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicityInternational Journal of Molecular SciencesDOI: 10.1186/1479-5876-9-13

2018

Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez-Barriocanal F, Morales AI, Lopez-Novoa JM.N-acetylcysteine transforms necrosis into apoptosis and affords tailored protection from cisplatin cytotoxicity.BioMed Research InternationalDOI: 10.1124/jpet.108.148254

Cabezas-Rodriguez I, Carrero JJ, Zoccali C, Qureshi AR, Ketteler M, Floege J, London G, Locatelli F, Gorriz JL, Rutkowski B, Memmos D, Ferreira A, Covic A, Teplan V, Bos WJ, Kramar R, Pavlovic D, Goldsmith D, Nagy J, Benedik M, Verbeelen D, Tielemans C, Wuthrich RP, Martin PY, Martinez-Salgado C, Fernandez-Martin JL, Cannata-Andia JB.Cardiotrophin 1 improves kidney preservation, graft function and survival in transplanted ratsFrontiers in PhysiologyDOI: 10.1038/ki.2010.267

Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-Sánchez EM, López-Montañés D, Quirós Y, López-Hernández FJ, Rodríguez-Pérez A, López-Novoa JMCardiotrophin-1 attenuates experimental colitis in micePLoS OneDOI: 10.1042/CS20080119

López-Hernández FJ.Influence of Angiogenic Mediators and Bone Remodelling in Paget´s Disease of Bone.Biomedicine & PharmacotherapyDOI: 10.1016/j.arr.2021.101408

2017

Sancho-Martínez SM, Piedrafita FJ, Cannata-Andía JB, López-Novoa JM, López-Hernández FJ.Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-tonephroprotective correlation.Biochimica et Biophysica Acta-Molecular Basis of DiseaseDOI: 10.33594/000000369

Sánchez-González PD, López-Hernandez FJ, Morales AI, Macías-Nuñez JF, López-Novoa JM.Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cellsBiomed Research InternationalDOI: 10.1016/j.biopha.2019.109684

Fernandes-Cerqueira C, Sampaio-Maia B, Quelhas-Santos J, Moreira-Rodrigues M, Simoes-Silva L, Blazquez-Medela AM, Martinez-Salgado C, Lopez-Novoa JM, Pestana M.A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity.Translational ResearchDOI: 10.3389/fphys.2021.645044

S. M. Sancho-Martínez, L. Prieto-García, M. Prieto, I. Fuentes-Calvo, J. M. López-Novoa, A. I. Morales, C. Martínez-Salgado, F. J. López-Hernández.Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues.Nephron ExtraDOI: 10.3390/genes12060800

I. Fuentes-Calvo, R. Usategui-Martín, I. Calero-Paniagua, C. Moledo-Pouso, L. García-Ortiz, J. Del Pino-Montes, R. González-Sarmiento, C. Martínez-Salgado.Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.Clinical Journal of the American Society of NephrologyDOI: 10.1016/j.trsl.2020.11.011.

2016

López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López Hernández FJ.Cardiotrophin-1 therapy prevents gentamicin-induced nephrotoxicity in rats.Journal of PhysiologyDOI: 10.1038/s41598-020-66238-9

Fuentes-Calvo I, Crespo P, Santos E, López-Novoa JM, Martinez-Salgado C.Absence of K-Ras reduces proliferation and migration but increases extracellular matrix synthesis in fibroblasts.Critical Reviews in ToxicologyDOI: 10.3389/fendo.2020.00289

Sánchez-González PD, López-Hernández FJ, Dueñas M, Prieto M, Sánchez-López E, Thomale J, Ruiz-Ortega M, López-Novoa JM, Morales AILamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus loadBiochimica et Biophysica Acta Molecular Cell ResearchDOI: 10.1038/s41598-020-68398-0

Casanova AG, Vicente-Vicente L, Hernández-Sánchez MT, Pescador M, Prieto M, Martínez-Salgado C, Morales AI, López-Hernández FJ.Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro.BloodDOI: 10.1136/bmjopen-2019-032918

Fuentes-Calvo I, Martinez-Salgado CMechanisms of Triple Whammy Acute Kidney Injury.Laboratory InvestigationDOI: 10.1080/10408444.2020.1837070

2015

Ferreira L, Quiros Y, Sancho-Martínez SM, García-Sánchez O, Raposo C, López-Novoa JM, González-Buitrago JM, López-Hernández FJ.Activation of the ALK-5 pathway is not per se sufficient for the antiproliferative effect of TGF-? on renal tubule epithelial cells.Toxicological ScienceDOI: 10.1038/s41598-019-54306-8

Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ.TGF-? and BMPs inhibitors in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?HypertensionDOI: 10.3390/ijms20194961

Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin G.Plasma cardiotrophin-1 as a marker of hypertension and diabetes-induced target organ damage and cardiovascular risk.Scientific ReportsDOI: 10.1093/toxsci/kfz242

Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Pescador M, López-Hernández FJ, Morales AI.Increased KLK9 urinary excretion is associated to hypertension-induced cardiovascular damage and renal alterationsToxicologyDOI: 10.1007/s00228-019-02771-5

Perretta-Tejedor N, Fernández-Mateos J, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Agudo-Conde C, Rodriguez-Sánchez E, Morales AI, López-Hernández FJ, López-Novoa JM, González-Sarmiento R, Martínez-Salgado C.Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase.European Journal of Clinical InvestigationDOI: 10.1042/CS20171513

Casanova AG, Prieto M, Colino CI, Gutiérrez-Millán C, Ruszkowska-Ciastek B, de Paz E, Martín Á, Morales AI, López-Hernández FJ.Urinary proteomics in renal pathophysiology: Impact of proteinuria.Scientific ReportsDOI: 10.1111/apha.13247

2014

Quiros Y, Vicente-Vicente L, Morales AI, López-Novoa JM, López-Hernández FJ.Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.American Journal of Physiology (Cell Physiology)DOI: 10.1016/j.taap.2018.04.010

Morales AI, Detaille D, Prieto M, Puente A, Briones E, Arévalo M, Leverve X, López-Novoa JM, El-Mir MY.Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.Journal of HypertensionDOI: 10.1016/j.tox.2016.12.003

Fuentes-Calvo I, Blázquez-Medela AM, Santos E, López-Novoa JM, Martínez-Salgado C.Interferon-? Reduces the Proliferation of Primed Human Renal Tubular Cells.BMC Cardiovascular DisordersDOI: 10.1016/j.bone.2016.01.005

Rossi E, Sanz-Rodriguez F, Eleno N, Düwel A, Blanco FJ, Langa C, Botella LM, Cabañas C, Lopez-Novoa JM, Bernabeu C.L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction.Frontiers in EndocrinologyDOI: 10.1038/srep41875

Martin-Sanchez D, Gallegos-Villalobos A, Fontecha-Barriuso M, Carrasco S, Sanchez-Niño MD, Lopez-Hernandez FJ, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB.Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a casecontrol study protocol (LOD-Hipertensión).ElectrophoresisDOI: 10.1016/j.tox.2017.04.015

Prieto García L, Pericacho M, Sancho-Martínez S, Sánchez A, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy.BMC Cardiovascular Disorders.DOI: 10.1016/j.pharmthera.2016.07.011

Casanova AG, Fuentes-Calvo I, Hernández-Sánchez MT, Quintero M, Toral P, Caballero MT, Martínez-Salgado C, Morales AI, Layton AT, Eleno N, López-Hernández FJ.ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts.Toxicological SciencesDOI: 10.7150/ijms.26580

2013

Blázquez-Medela AM, López-Novoa JM, Martínez-Salgado C.Concerted action of ANP and dopamine D1 receptor to regulate sodium homeostasis in puromycin aminonucleoside-induced nephrotic syndrome.Cell Tissue ResearchDOI: 10.1159/000430246

Grande MT, Fuentes-Calvo I, Arévalo M, Heredia F, Santos E, Martínez-Salgado C, Rodríguez-Puyol D, Nieto MA, López-Novoa JM.Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.BMC Public HealthDOI: 10.1097/MD.0000000000001218

Gómez-Marcos MA, Martínez-Salgado C, Grandes G, Recio-Rodriguez JI, Castaño Sánchez Y, Rodríguez-Sánchez E, García-Ortiz L.Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.Molecular and Cellular EndocrinologyDOI: 10.1136/bmjopen-2014-005112

Quiros Y, Sánchez-González PD, López-Hernández FJ, Morales AI, López-Novoa JM.The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts.BMJ OpenDOI: 10.1002/prca.201400183

Quirós-González I, Román-García P, Alonso-Montes C, Barrio-Vázquez S, Carrillo-López N, Naves-Díaz M, Mora MI, Corrales FJ, López-Hernández FJ, Ruiz-Torres MP, Cannata-Andía JB, Fernández-Martín JL.In?uence of Body Mass Index on the Association of Weight Changes with Mortality in Hemodialysis Patients.Pharmacology & TherapeuticsDOI: 10.1016/j.cellsig.2016.05.015

Quirós Y, Blanco-Gozalo V, Sanchez-Gallego JI, López-Hernández FJ, Ruiz J, Perez de Obanos MP, López-Novoa JM.Stomatin-domain protein interactions with acid sensing ion channels modulate nociceptor mechanosensitivity.Journal of Translational Medicine 9: 13, 2011DOI: 10.1016/j.pharmthera.2015.10.003

Muñoz-Félix JM, Fuentes-Calvo I, Cuesta C, Eleno N, Crespo P, López-Novoa JM, Martínez-Salgado C.Increased urinary excretion of albumin, hemopexin, transferrin and VDBP correlates with chronic sensitization to gentamicin nephrotoxicity in rats.Current Molecular MedicineDOI: 10.1016/j.bbamcr.2014.02.017

Alfredo G. Casanova, Laura Vicente-Vicente, M. Teresa Hernández-Sánchez, Marta Prieto, M. Isabel Rihuete, Laura M. Ramis, Elvira del Barco, Juan J. Cruz, Alberto Ortiz, Ignacio Cruz-González, Carlos Martínez-Salgado, Moisés Pescador, Francisco J. López-Hernández, Ana I. Morales.TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast.Scientific ReportsDOI: 10.1016/j.phrs.2016.02.025

2012

López-Novoa JM, Martínez-Salgado C, Rodríguez-Peña AB, López Hernández FJ.Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.Nephrology Dialysis and Transplantation. 26: 3484-3495, 2011.DOI: 10.1159/000353587

Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodríguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.Office and 24-hour heart rate and target organ damage in hypertensive patients.Toxicological LettersDOI: 10.1016/j.bbamcr.2013.07.008

Vicente-Vicente L, Ferreira L, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.Osteoprotegerin Is Associated To Cardiovascular Risk In Hypertension And/Or Diabetes.Acta PhysiologicaDOI: 10.1371/journal.pone.0105988

Ghosh S, Kapil V, Fuentes-Calvo I, Bubb K, Pearl V, Milsom A, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb W, Caulfield M, Hobbs A.Subcellular targets of cisplatin cytotoxicity: an integrated view.European Journal of Clinical PharmacologyDOI: 10.1113/jphysiol.2013.261180

Muñoz-Félix JM, Cuesta C, Perretta-Tejedor N, Subileau M, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.H-Ras isoform modulates extracellular matrix synthesis, proliferation and migration in fibroblasts.Critical Review in ToxicologyDOI: 10.1155/2014/124902

García-Sánchez O, Sancho-Martínez SM, López-Novoa JM, López-Hernández FJ.Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive.Toxicological SciencesDOI: 10.1155/2013/397391

Sancho-Martínez SM, Prieto-García L, Blanco-Gozalo V, Fontecha M, López-Novoa JM, López-Hernández FJ.Role of TGF-? in chronic kidney disease: an integration of tubular, glomerular and vascular effects.Journal of Translational MedicineDOI: 10.1093/toxsci/kft007

Prieto-Garcia L, Vicente-Vicente L, Blanco-Gozalo V, Hidalgo-Thomas O, Garcia-Macias MC, Kurtz A, Layton AT, Sanz A, Morales AI, Martinez-Salgado C, Pericacho M, Sancho-Martinez S, Lopez-Hernandez FJ. A new tool to assess retinal vessel caliber. Reliability and validity of measures and their relationship with cardiovascular risk.International Journal of Molecular SciencesDOI: 10.1016/j.bbadis.2013.05.032

2011

Quiros Y, Ferreira L, Sancho-Martínez SM, González-Buitrago JM, López-Novoa JM, López-Hernández FJ.Functional expression of angiotensinogen depends on a splicing enhancers in exon 2.Toxicological SciencesDOI: 10.1002/elps.201100606

Núñez R, Sancho-Martínez SM, Novoa JM, López-Hernández FJ.Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis.PLoS OneDOI: 10.1016/j.pharmthera.2012.07.003

Vicente-Vicente L, Quiros Y, Pérez-Barriocanal F, López-Novoa JM, López-Hernández FJ, Morales AI.Urinary levels of regenerating islet-derived protein III ? and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats.Kidney InternationalDOI: 10.2174/156652411795976565

García-Sánchez O, López-Hernández FJ, López-Novoa JM.Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.Pharmacology & TherapeuticsDOI: 10.1093/toxsci/kfr098

L. Gamella-Pozuelo, I. Fuentes-Calvo, M. A. Gómez-Marcos, J. I. Recio-Rodriguez, C. Agudo-Conde, J. L. Fernández-Martín, J. B. Cannata-Andía, J. M. López-Novoa, L. García-Ortiz, C. Martínez-Salgado.Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.Current Diabetes ReviewsDOI: 10.1186/1471-2458-11-266

Vicente-Vicente L, Sánchez-Juanes F, García-Sánchez O, Blanco-Gozalo V, Pescador M, Sevilla MA, González-Buitrago JM, López-Hernández FJ, López-Novoa JM, Morales AI.An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin.Medicina ClínicaDOI: 10.1093/ndt/gfr195

Blázquez-Medela AM, García-Sánchez O, Blanco-Gozalo V, Quiros Y, Montero MJ, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ.An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease.Clinical ScienceDOI: 10.1038/cdd.2010.96

Blázquez-Medela AM, García-Ortiz L, Gómez-Marcos MA, Recio-Rodriguez JI, Sánchez-Rodríguez A, López-Novoa JM, Martínez-Salgado C.An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity.Toxicological SciencesDOI: 10.1097/HJH.0b013e3283506628

Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C.New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view.Clinical ScienceDOI: 10.1016/j.mce.2010.10.016

Blázquez-Medela M, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.Osteoprotegerin and diabetes-associated pathologies.Kidney InternationalDOI: 10.1152/ajpcell.00103.2011

Muñoz-Félix M, González-Núñez M, Martínez-Salgado C, López-Novoa JM.Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity.Kidney InternationalDOI: 10.1186/1471-2261-12-19

Blanco-Gozalo V, Casanova AG, Sancho-Martínez SM, Prieto M, Quiros Y, Morales AI, Martínez-Salgado C, Agüeros-Blanco C, Benito-Hernández A, Ramos-Barron MA, Gómez-Alamillo C, Arias M, López-Hernández FJ.Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study.TransplantationDOI: 10.1161/HYPERTENSIONAHA.111.00933

Garzón-Martínez M, Perretta-Tejedor N, Garcia-Ortiz L, Gomez-Marcos M, Gonzalez-Sarmiento R, Lopez-Hernandez F, Martinez-Salgado C.Effects of deferasirox on renal function and renal epithelial cell death.Toxicology and Applied PharmacologyDOI: 10.1007/s00441-011-1275-6

2010

Gómez-Marcos MA, Martínez-Salgado C, Martín-Cantera C, Recio-Rodríguez JI, Castaño-Sánchez Y, Giné-Garriga M, Rodríguez E, García-Ortiz L.Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients.Cell Death & Differentiation 17: 1665-1671, 2010.DOI: 10.2174/157339910790909422

García-Ortiz L, Gómez-Marcos MA, Martín-Moreiras J, González-Elena LJ, Recio-Rodriguez JI, Castaño-Sánchez Y, Grandes G, Martínez-Salgado C.Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies.Kidney InternationalDOI: 10.1186/1741-7015-8-86

Fernández-Campo L, Grande MT, Diego J, Fuentes-Calvo I, Macías-Núñez JF, Sánchez-Rodríguez A, Grande J, García-Ortiz L, López-Novoa JM, Martínez-Salgado C.Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.Head and NeckDOI: 10.1038/ki.2010.337

García-Ortiz L, Recio-Rodríguez JI, Parra-Sanchez J, González-Elena LJ, Patino-Alonso MC, Agudo-Conde C, Rodríguez-Sánchez E, Gómez-Marcos MA; Vaso-risk group.Nephrotoxicity of uranium: pathophysiological, diagnostic and therapeutic perspectives.ToxicologyDOI: 10.1002/hed.21248

Ferreira L, Fuentes-Calvo I, Muñoz-Félix JM, Muñiz C, Sánchez-Juanes F, Raposo C, González-Buitrago JM, López-Novoa JM, Martínez-Salgado C.Lesión orgánica subclínica y nefropatía en hipertensos de nuevo diagnóstico.International Journal of Medical SciencesDOI: 10.1093/toxsci/kfq267

Muñoz-Félix JM, López-Novoa JM, Martínez-Salgado C.Mechanisms involved in the genesis of diabetic nephropathy.BMC MedicineDOI: 10.1038/ki.2010.439

Muñoz-Félix JM, Perretta-Tejedor N, Eleno N, López-Novoa JM, Martínez-Salgado C.Common pathophysiological mechanisms of chronic kidney diseases: therapeutic perspectivas.Kidney InternationalDOI: 10.1371/journal.pone.0008703

Gomez-Marcos MA, Gonzalez-Sarmiento R, Recio-Rodríguez JI, Agudo-Conde C, Gamella-Pozuelo L, Perretta-Tejedor N, Martínez-Salgado C, García-Ortiz L.Sub-nephrotoxic doses of gentamicin predispose animals to developing acute kidney injury and to excrete ganglioside M2 activator protein.Toxicological SciencesDOI: 10.1016/j.pharmthera.2010.05.006

Martin WP, White J, López-Hernández FJ, Docherty NG, le Roux CW.Analysis of K-ras nuclear expression in fibroblasts and mesangial cells.Food and Chemical ToxicologyDOI: 10.1016/j.toxlet.2011.03.018

Sancho-Martínez SM, Blanco-Gozalo V, Quiros Y, Prieto-García L, Montero-Gómez MJ, Docherty NG, Martínez-Salgado C, Morales AI, López-Novoa JM, López-Hernández FJ. Endoglin as a marker in cervical paragangliomas.ToxicologyDOI: 10.1038/ki.2009.498

2009

Collaborating Companies

Patents

P201031407. Fecha de solicitud: 22 de septiembre de 2010. Título: “Método para la detección de daño renal”.